PROOF OF CONCEPT

RNatives is actively investigating the potential uses of novel nuclear microRNA biology to address various diseases. 

OUR KEY PUBLICATIONS

1.

Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, et al. Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res. 2009;105:604-9.
Link: https://pubmed.ncbi.nlm.nih.gov/19696410/

2.

Turunen MP, Husso T, Musthafa H, Laidinen S, Dragneva G, Laham-Karam N, et al. Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice. PLoS One. 2014;9:e89979.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935957/

3.

Turunen TA, Roberts TC, Laitinen P, Väänänen MA, Korhonen P, Malm T, Ylä-Herttuala S, Turunen MP. Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress.SciRep. 2019 Jul 17;9(1):10332.
Link: https://pubmed.ncbi.nlm.nih.gov/31316122/

4.

Turunen TA, Ylä-Herttuala S, Turunen MP. Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs. Adv Exp Med Biol. 2017;983:195-205.
Link: https://pubmed.ncbi.nlm.nih.gov/28639201/

5.

Laitinen P, Väänänen MA, Kolari IL, Mäkinen PI, Kaikkonen MU, Weinberg MS, Morris KV, Korhonen P, Malm T, Ylä-Herttuala S, Roberts TC, Turunen MP, Turunen TA. Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia. PLoS One. 2022 Mar 31;17(3):e0265948.
Link: https://pubmed.ncbi.nlm.nih.gov/35358280/

SIGNIFICANT PUBLICATIONS BY OTHERS

1.

Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13. Epub 2008 Jan 28.
Link: https://pubmed.ncbi.nlm.nih.gov/18227514/

2.

Li LC, Okino ST, Zhao H, Pokot D, Place RF, Dahiya R. Small double-stranded RNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA. 2006 Nov 14;103(46):17337-17342
Link: https://pubmed.ncbi.nlm.nih.gov/17085592/

3.

Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell Res. 2016 Feb 23.
Link: https://pubmed.ncbi.nlm.nih.gov/26902284/